Bioinformatic analysis reveals MIR502 as a potential tumour suppressor in ovarian cancer

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Tumour suppressor genes and risk of metastasis in ovarian cancer.

The silent onset of ovarian cancer often leads to metastatic spread before diagnosis can be made. The cause remains unknown, but molecular studies are beginning to reveal some mechanisms. Inactivation of tumour suppressor genes is thought to be responsible for initiating many forms of cancer. Studies of allele loss indicate areas of genome where inactivation may occur. We recently examined the ...

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Methylation analysis of tumour suppressor genes in ovarian cancer using MS-MLPA.

Epigenetic changes are considered to be a frequent event during tumour development. Hypermethylation of promoter CpG islands represents an alternative mechanism for inactivation of tumour suppressor genes, DNA repair genes, cell cycle regulators and transcription factors. The aim of this study was to investigate promoter methylation of...

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GPER-1 acts as a tumor suppressor in ovarian cancer

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Promoter Hypermethylation of Tumour Suppressor Genes as Potential Biomarkers in Colorectal Cancer

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ژورنال

عنوان ژورنال: Journal of Ovarian Research

سال: 2020

ISSN: 1757-2215

DOI: 10.1186/s13048-020-00683-y