Bioinformatic analysis reveals MIR502 as a potential tumour suppressor in ovarian cancer
نویسندگان
چکیده
منابع مشابه
Tumour suppressor genes and risk of metastasis in ovarian cancer.
The silent onset of ovarian cancer often leads to metastatic spread before diagnosis can be made. The cause remains unknown, but molecular studies are beginning to reveal some mechanisms. Inactivation of tumour suppressor genes is thought to be responsible for initiating many forms of cancer. Studies of allele loss indicate areas of genome where inactivation may occur. We recently examined the ...
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Epigenetic changes are considered to be a frequent event during tumour development. Hypermethylation of promoter CpG islands represents an alternative mechanism for inactivation of tumour suppressor genes, DNA repair genes, cell cycle regulators and transcription factors. The aim of this study was to investigate promoter methylation of...
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BACKGROUND It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease progression. This study was conducted to evaluate the GPER-1 expression in ovarian cancer and its correlation with progression. Its function was tested in vitro in ovarian cancer cells. PATIENTS AND METHODS GPER-1 expression was analyz...
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Maspin is a protein that belongs to serin protease inhibitor (serpin) superfamily. The purpose of this study was to review the literature concerning the expression of maspin in salivary gland tumours. A literature search was done using MEDLINE, accessed via the National Library of Medicine PubMed interface. Statistical analysis was not done because only seven studies were available in literatur...
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ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2020
ISSN: 1757-2215
DOI: 10.1186/s13048-020-00683-y